- The virus penetrates the nasal mucosa, performs its first cycle of replication in the epithelial cells and extends through the lacrimal ducts to the ocular tissues where it establishes secondary infection.
- Subsequently, generalized infection occurs as a result of transient viremia and neural dissemination and / or intercellular bridges that allow the virus to reach the target organ (Duque et al., 2014).
- Infections of the upper respiratory tract or genital tract may occur, these infections are usually self-limiting and the infection of the animal lasts 1 to 2 weeks (Martínez and Riveira, 2008).
- In the case of genital infections, the virus directly reaches the target organ (mucosa of the vulva, penis and foreskin). (Duque et al., 2014).
- The abortigenic manifestation, the virus reaches the fetus via hematogen, infects the fetus and causes the death of the fetus. The virus can cause a systemic invasion when transported by monocytes and peripheral leukocytes, reaching the placenta and the fetus, producing abortion, but is observed mainly in the last third of gestation (Duque et al., 2014).
- Reference
Martinez, P.
Riviera, L. (2008).Antecedentes, generalidades y actualizacion en
aspectos de patogénesis, diagnóstico y control de la diarrea viral bovina (DVB)
y rinotraqueitis infecciosa bovina (IBR). Pontificia Universidad Javeriana.
Duque,
D., Estévez, J., Abreu, A., Moncada, M., Durango, J., Molina, D. (2014). Aspectos
sobre Rinotraqueítis Infecciosa Bovina. Journal
of agriculture and animal sciences. Vol 3:1; 58-71. Recuperado de: http://repository.lasallista.edu.co/dspace/bitstream/10567/1193/1/619-1606-1-PB.pdf
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